Non-Sentinel Lymph Node Metastasis is Hard to Predict by Clinicopathological Factors if SLN Metastasis in Two or Fewer Nodes in Breast Cancer

Miki Hasegawa, Yu Koyama, Jun Sakata, Kumiko Tatsuda, Eiko Sakata, Chie Toshikawa, Naoko Manba, Mayuko Ikarashi, Toshifumi Wakai

Abstract


Background: The aim of this study was to investigate the association between sentinel lymph node (SLN) and/or non-SLN metastasis and clinicopathological factors in breast cancer.

Methods: We identified 176 invasive breast cancer patients by SLN biopsy (SLNB) and evaluated any association between clinicopathological factors and SLN and/or non-SLN metastasis.

Results: SLN metastasis was significantly associated with age (P = 0.0231), tumor size (P = 0.0039) and lymphovascular involvement (LVI) (P = 0.0002). Non-SLN metastasis was observed in 41.4% of cases. The involvement of more than three nodes was observed in more than 30% of cases with SLN metastasis in two or fewer nodes. There was no significant association between non-SLN metastasis and clinicopathological factors.

Conclusions: Non-SLN metastasis was apparent in more than 30% of cases even if SLN metastasis was present in two or fewer nodes but non-SLN metastasis was hard to predict by clinicopathological factors.




J Curr Surg. 2014;4(1):10-16
doi: http://dx.doi.org/10.14740/jcs206w


Keywords


Breast cancer; Sentinel lymph node; Non-sentinel lymph node; Metastasis

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