Journal of Current Surgery, ISSN 1927-1298 print, 1927-1301 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Curr Surg and Elmer Press Inc
Journal website http://www.currentsurgery.org

Original Article

Volume 1, Number 1, December 2011, pages 12-18

A Comparison of Dexmedetomidine and Midazolam for Sedation in Gynecologic Surgery Under Epidural Anesthesia

Figures

Figure 1.
Figure 1. Heart rate (HR, beats/min) variables during study drug infusion (T0-T7), the end of surgical procedures (T8), recovery period (T9-T12). HR in group DEX was significantly lower than Group MDZ ((P < 0.001). The time scale is not linear.
Figure 2.
Figure 2. Mean artery pressure (MAP, mmHg) was similar between groups (all P > 0.05).
Figure 3.
Figure 3. Ramsay Sedation Scale (RSS) score (units) was similar between groups (all P > 0.05).
Figure 4.
Figure 4. Bispectral index (BIS) values (units) in group DEX was significantly lower than Group MDZ during surgical procedures (P < 0.001) , and similar during recovery period(P > 0.05).

Table

Table 1. The Patients’ Characteristics and Perioperative Data.
 
VariableMDZ group (n = 63)DEX group (n = 61)P Value
Data are given as mean ± standard deviation or as percentage.
Age (y)50 ± 649 ± 40.391
Weight (kg)68 ± 367 ± 80.947
ASA Grade
  152 (97%)53 (97%)0.504
  211 (3%)8 (3%)
RASS of three or above (n, %)61 (97%)61 (100%)0.162
Operative time (min)101 ± 30102 ± 410.879
Total fentanyl dose (mg)54 ± 1117 ± 70.016
Bradycardia (n, %)3110.020
Hypotension (n, %)1080.664
Respiratory depression (n, %)800.004
Recovery time (min)45 ± 842 ± 50.495
Mean patients’ satisfaction score890.779
Mean surgeons’ satisfaction score990.834