J Curr Surg

Journal of Current Surgery, ISSN 1927-1298 print, 1927-1301 online, Open Access

Article copyright, the authors; Journal compilation copyright, J Curr Surg and Elmer Press Inc

Journal website http://www.currentsurgery.org

Original Article

Volume 9, Number 4, December 2019, pages 45-50

Analysis of Transfusion Volumes in the Elderly Trauma Population

Figure 2. Figure 2. Kaplan-Meier 100-day survival curves according to FFP transfusion. FFP: fresh frozen plasma.

**Table 1.** Characteristics of Transfused Elderly Trauma Patients
	Transfused study population (N = 94)	Survivor (N = 59)	Non-survivor (N = 35)	P value
LOS: length of hospital stay; SD: standard deviation; PRBC: packed red blood cell; FFP: fresh frozen plasma; ISS: injury severity score.
LOS (days)				< 0.001
Mean	8.80	11.46	4.37
Median	6.0	9	1
Range	1 - 37	1 - 37	1 - 25
SD	8.60	8.99	5.87
Age (years)				0.2262
Mean	77.73	78.22	76.80
Median	78.0	79.0	77.0
Range	65 - 101	65 - 97	65 - 101
SD	8.32	8.15	8.66
Female (%)	60.22	58.62	62.86	0.6551
Male (%)	39.78	41.38	37.14	0.6551
PRBC (% received)	66.67	67.2	65.71	0.8813
FFP (% received)	33.33	24.13	48.57	0.0152
Platelets (% received)	3.73	29.31	28.57	0.9402
Total no. of products				0.0044
Mean	3.73	2.87	5.14
Median	2.5	2	5.5
Range	1 - 20	1 - 12	1 - 20
SD	4.05	2.41	8.20
Blunt injury (%)	92.47	93.11	97.14	< 0.0001
Penetrating injury (%)	7.53	6.89	2.86	< 0.0001
Received ≥ 5 units (%)	19.52%	12.06%	45.71%	0.0002
ISS				< 0.001
Mean	19.13	16.13	25.11
Median	17	14	25
Range	1 - 75	1 - 43	9 - 75
SD	10.47	8.19	11.52
ISS ≥ 16 (%)	37.63	43.10	85.71	< 0.001

Table 1. Characteristics of Transfused Elderly Trauma Patients

Transfused study population (N = 94)

Survivor (N = 59)

Non-survivor (N = 35)

P value

LOS: length of hospital stay; SD: standard deviation; PRBC: packed red blood cell; FFP: fresh frozen plasma; ISS: injury severity score.

LOS (days)

< 0.001

Mean

8.80

11.46

4.37

Median

6.0

Range

1 - 37

1 - 25

8.60

8.99

5.87

Age (years)

0.2262

Mean

77.73

78.22

76.80

Median

78.0

79.0

77.0

Range

65 - 101

65 - 97

65 - 101

8.32

8.15

8.66

Female (%)

60.22

58.62

62.86

0.6551

Male (%)

39.78

41.38

37.14

0.6551

PRBC (% received)

66.67

67.2

65.71

0.8813

FFP (% received)

33.33

24.13

48.57

0.0152

Platelets (% received)

3.73

29.31

28.57

0.9402

Total no. of products

0.0044

Mean

3.73

2.87

5.14

Median

2.5

5.5

Range

1 - 20

1 - 12

1 - 20

4.05

2.41

8.20

Blunt injury (%)

92.47

93.11

97.14

< 0.0001

Penetrating injury (%)

7.53

6.89

2.86

< 0.0001

Received ≥ 5 units (%)

19.52%

12.06%

45.71%

0.0002

ISS

< 0.001

Mean

19.13

16.13

25.11

Median

Range

1 - 75

1 - 43

9 - 75

10.47

8.19

11.52

ISS ≥ 16 (%)

37.63

43.10

85.71

< 0.001

**Table 2.** Cox Proportional Analysis: Independent Predictors of Mortality
Variable	Hazard ratio	P value
FFP: fresh frozen plasma; ISS: injury severity score.
Age (per year)	1.0232	0.05
Gender	1.5	0.048
Number of units received	1.52	< 0.001
Received FFP	14.73	< 0.001
ISS	1.233	< 0.001
Severe injury (ISS > 16)	17.732	< 0.001

Table 2. Cox Proportional Analysis: Independent Predictors of Mortality

Variable

Hazard ratio

P value

FFP: fresh frozen plasma; ISS: injury severity score.

Age (per year)

1.0232

0.05

Gender

1.5

0.048

Number of units received

1.52

< 0.001

Received FFP

14.73

< 0.001

ISS

1.233

< 0.001

Severe injury (ISS > 16)

17.732

< 0.001

**Table 3.** Hazard Ratio for Transfusion Groups
Transfusions	Hazard ratio	P value	95% CI
CI: confidence interval.
< 5 Units	2.48	0.01	1.46 - 4.20
≥ 5 Units	6.27	< 0.001	3.62 - 10.88

Table 3. Hazard Ratio for Transfusion Groups

Transfusions

Hazard ratio

P value

95% CI

CI: confidence interval.

< 5 Units

2.48

0.01

1.46 - 4.20

≥ 5 Units

6.27

< 0.001

3.62 - 10.88

**Table 4.** ISS Stratified by Transfusion Group
Transfusions	< 5 Units	≥ 5 Units	P value
ISS: injury severity score.
Mean ISS	18.629	22.217	0.1475

Table 4. ISS Stratified by Transfusion Group

Transfusions

< 5 Units

≥ 5 Units

P value

ISS: injury severity score.

Mean ISS

18.629

22.217

0.1475

**Table 5.** LOS Based on Transfusion Volume
Transfusions	LOS	P value	95% CI
LOS: length of hospital stay; CI: confidence interval.
< 5 Units	5.19	< 0.01	3.68 - 6.70
≥ 5 Units	12.47	< 0.01	8.37 - 16.56

Table 5. LOS Based on Transfusion Volume

Transfusions

LOS

P value

95% CI

LOS: length of hospital stay; CI: confidence interval.

< 5 Units

5.19

< 0.01

3.68 - 6.70

≥ 5 Units

12.47

< 0.01

8.37 - 16.56

**Table 6.** Hazard Ratio
	Hazard ratio	P value	95% CI
FFP: fresh frozen plasma; CI: confidence interval.
Received FFP	3.25	< 0.001	1.91 - 5.53

Table 6. Hazard Ratio

Hazard ratio

P value

95% CI

FFP: fresh frozen plasma; CI: confidence interval.

Received FFP

3.25

< 0.001

1.91 - 5.53