| Journal of Current Surgery, ISSN 1927-1298 print, 1927-1301 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Curr Surg and Elmer Press Inc |
| Journal website https://www.currentsurgery.org |
Original Article
Volume 12, Number 1, March 2022, pages 1-6
Preoperative Administration of Aprepitant to Prevent Postoperative Nausea and Vomiting in Children
Tables
| Variables | N (%) or mean ± SD |
|---|---|
| N: number; SD: standard deviation. | |
| Age (years) | 13.7 ± 2.5 |
| ≤ 3 | 0 |
| 4 - 7 | 4 (2.8%) |
| 8 - 12 | 41 (28.4%) |
| 13 - 17 | 99 (68.8%) |
| Weight (kg) | 70.5 ± 36.7 |
| Gender | |
| Male | 67 (47%) |
| Female | 77 (53%) |
| Visit type | |
| Inpatient surgery | 87 (60.4%) |
| Outpatient surgery | 57 (39.6%) |
| Variable | Number |
|---|---|
| Gastrointestinal surgery | 38 |
| Upper endoscopy | 1 |
| Neurosurgery | 3 |
| Ophthalmological | 6 |
| Orthopedic surgery | 27 |
| Otolaryngologic | 21 |
| Radiologic imaging | 9 |
| Renal or urology | 8 |
| General surgery and others | 31 |
| Variable | N (%) or mean (SD) |
|---|---|
| Data presented as n (%) or mean (SD). N: number; SD: standard deviation; PONV: postoperative nausea and vomiting; PACU: postanesthesia care unit. | |
| History of PONV following previous surgical procedures | |
| Yes | 62 (43.1%) |
| No | 82 (56.9%) |
| Aprepitant product | |
| Capsule | 142 (98.6%) |
| Liquid | 2 (1.4%) |
| Dose of aprepitant administered | |
| 40, 80 or 125 mg | 141 (97.9%), 2 (1.4%), 1 (0.7%) |
| Average dose of aprepitant (mg/kg) | 0.7 (0.3) |
| Contraindications to use of ondansetron or dexamethasone | |
| None | 142 (98.6%) |
| Prolonged QT interval, first-degree heart block | 1 (0.7%) |
| Yes (ondansetron allergy) | 1 (0.7%) |
| Intraoperative dexmedetomidine (yes/no) | 83 (57.6%)/61 (42.4%) |
| Number of additional antiemetic agents administered intraoperatively | |
| 0, 1, 2, 3 | 2, 24, 98, 20 |
| Other antiemetic agents administered intraoperatively | |
| Diphenhydramine | 1 |
| Dexamethasone | 130 |
| Metoclopramide | 15 |
| Ondansetron | 123 |
| Promethazine | 3 |
| Scopolamine patch | 8 |
| Antiemetic agents required postoperatively (yes/no) | 17 (11.8%)/127 (88.2%) |
| Antiemetic agents administered postoperatively | |
| Dexamethasone | 2 |
| Ondansetron | 12 |
| Palonosetron | 2 |
| Promethazine | 2 |
| Other | 9 |
| Intraoperative opioids (yes/no) | 115 (79.9%)/29 (20.1%) |
| Intraoperative opioids | |
| Fentanyl | 83 |
| Hydromorphone | 69 |
| Methadone | 6 |
| Morphine | 7 |
| Remifentanil | 6 |
| Sufentanil | 2 |
| PONV in PACU/postoperatively (yes/no) | 17 (11.8%)/127 (88.2%) |
| Duration of stay in PACU (min) | 116.5 (99.9) |
| Length of stay postoperatively (days) | 1.5 (3.9) |