Journal of Current Surgery, ISSN 1927-1298 print, 1927-1301 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Curr Surg and Elmer Press Inc
Journal website

Case Report

Volume 12, Number 2, December 2022, pages 45-49

A Large Myofibroblastoma of the Breast in a Premenopausal Woman: A Case Report and Review of the Literature


Figure 1.
Figure 1. Breast imaging showing circumscribed oval heterogeneous high density mainly hyperechoic mass in the right breast at 10 o’clock. (a) Mammography. (b) Ultrasonography.
Figure 2.
Figure 2. Image of the surgical specimen.
Figure 3.
Figure 3. Cut section of the tumor showing myxoid material mixed with yellowish fatty component, and grayish white slimy solid central area.
Figure 4.
Figure 4. (a) Microscopic examination showing myofibroblastic spindle cell clusters and stellate cells interspersed with collagenous fibers, adipocytes, and myxoid areas. (b) Higher magnification scattered mild cellular pleomorphism with hyperchromatic nuclei. (c) Higher magnification, bipolar spindle cells arranged in intersecting fascicles in focal myxoid area.


Table 1. Morphologic Variants of Myofibroblastoma
MFB: myofibroblastoma.
CellularDense proliferation of spindle cells, usually with infiltrative boarder.
EpithelioidMFB composed exclusively or predominantly (> 50%) of epithelioid cells.
Deciduoid-likeLarger cells with copious eosinophilic cytoplasm, vesicular nuclei, with single or multiple prominent nucleoli.
Collagenized/fibrousHighly collagenous stroma.
InfiltrativeInvasive growth pattern, entrapping surrounding glandular tissue and fat.
LipomatousMFB composed predominantly (i.e., > 75% of the entire neoplasm) of adipocytes.
MyxoidEntirely or predominantly myxoid stroma in which spindle cells and stellate cells are embedded.
MixedTwo or more variants coexisting in the same tumor.