| Journal of Current Surgery, ISSN 1927-1298 print, 1927-1301 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Curr Surg and Elmer Press Inc |
| Journal website https://www.currentsurgery.org |
Short Communication
Volume 13, Number 1, September 2023, pages 12-16
Impact of Gastroesophageal Reflux Disease on Patients Undergoing Lung Transplantation for COVID-19: A Single Institution Retrospective Study
Tables
| Patients who underwent lung transplant for COVID-19 (n = 17) | |
|---|---|
| VV ECMO: veno-venous extracorporeal membrane oxygenation; BMI: body mass index; PEG: percutaneous endoscopic gastrostomy; PPI: proton pump inhibitor. | |
| Gender | |
| Male | 17/17 |
| Female | 0/17 |
| Ethnicity | |
| Caucasian | 6/17 |
| Hispanic | 9/17 |
| Black | 2/17 |
| Median age at transplant | 50 |
| Mean age at transplant | 48 |
| Range of age at transplant | 24 - 70 |
| Median BMI | 28.9 |
| Mean BMI | 31.5 |
| Median time from documented COVID-19 infection to transplant | 131 days |
| Mean time from documented COVID-19 infection to transplant | 163 days |
| Requirement of VV ECMO | 13/17 |
| GI symptoms reported prior to transplant | 5/17 |
| Reflux | 5/5 |
| Comorbidities | |
| Obesity (BMI > 30) | 8/17 |
| Hiatal hernia | 2/17 |
| Pre-transplant testing/workup for reflux disease | |
| Yes | 3/17 |
| No | 14/17 |
| Testing/workup performed | |
| Upper endoscopy | 3/3 |
| Reason for pre-transplant testing | |
| Gastrointestinal bleed | 3/3 |
| PEG tube placement | 1/3 |
| On PPI prior to transplant | 2/17 |
| On PPI post-transplant | 17/17 |
| Patients who underwent lung transplant for COVID-19 (n=17) | |
|---|---|
| EGD: esophagogastroduodenoscopy; EGJOO: esophagogastric junction outlet obstruction; IEM: ineffective esophageal motility; ARS: anti-reflux surgery. | |
| Post-operative foregut symptoms | 12/17 |
| Cough | 7/12 |
| Early satiety | 1/12 |
| Abdominal bloating | 4/12 |
| Abdominal pain | 2/12 |
| Nausea and/or vomiting | 5/12 |
| Dysphagia | 1/12 |
| Reflux symptoms (heartburn or regurgitation) | 1/12 |
| Post-operative foregut studies completed | 17/17 |
| Gastric emptying study | 14/17 |
| Normal | 6/14 |
| Delayed gastric emptying at 4 h | 6/14 |
| Incomplete studies | 2/14 |
| Barium esophagram | 7/17 |
| Normal | 5/7 |
| Abnormal | 2/7 |
| EGD | 2/17 |
| Normal | 1/3 |
| Abnormal | 1/3 |
| pH study (capsule or impedance manometry) | 6/17 |
| Normal | 2/6 |
| Abnormal | 1/6 |
| Incomplete studies | 3/6 |
| Non-adherence to study | 2/3 |
| Unable to tolerate study | 1/3 |
| Esophageal manometry | 3/17 |
| Normal | 1/3 |
| EGJOO | 1/3 |
| IEM | 1/3 |
| Bronchoscopy | 3/3 |
| Positive cultures | 2/3 |
| Referral for ARS | 3/17 |
| Toupet fundoplication completed | 3/3 |
| Hiatal hernia repair completed | 2/3 |
| Median time from transplant to ARS | 240 days |
| Mean time from transplant to ARS | 189 days |
| Range of time from transplant to ARS | 73 - 255 days |