Incidence of Argyrophil Cells in Normal and Dysplastic Conditions of Human Uterine Cervix

Sujatha D'Costa, Raghuveer C’Vasudevarao, Adhikari Prabha, Sampath Madhyasta, Chitra Prakash Rao


Background: Cervical intraepithelial neoplasia, also known as cervical dysplasia, is the potentially premalignant transformation and abnormal growth of squamous cells on the surface of the cervix. Argyrophil cells occur rarely in the normal human uterine cervix but are found in a variety of invasive tumours arising in the cervix.

Methods: In this study, with the Grimelius argyrophilic reaction 317 normal uterine cervices were stained, out of which 158 cases (49.84%) were positive. And 27 dysplastic cases of uterine cervices were stained with Grimelius argyrophilic reaction, out of which 25 (92.59%) showed the argyrophilic positivity. When Normal cervix was compared with Dysplastic cervix the probability value was < 0.001 which was significantly higher. The immunomarkers used in the present study were Chromogranin A and Synaptophysin.

Results: Argyrophil cells in ectocervical epithelium are rare. It is the first study which reveals the comparison of the presence of argyrophilic cells in normal and dysplastic human uterine cervix, using Grimelius argyrophilic reaction and Immunohistochemical staining using Chromogranin A and Synaptophysin as argyrophilic markers with larger sample size and higher positivity.

Conclusion: From the results of our study it is clear that argyrophilia is a significant marker in dysplasia.



Argyrophil cells; Grimelius reaction; Markers; Neuroendocrine cells; Dysplasia; Normal cervix; Synaptophysin; Chromogranin A

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