Comparison of the Clinical Efficacies of Fentanyl, Esmolol and Lidocaine in Preventing the Hemodynamic Responses to Endotracheal Intubation and Extubation

Habib Bostan, Ahmet Eroglu


Background: We compared the efficacy of intravenous fentanyl, esmolol and lidocaine in preventing hemodynamic response to laryngoscopy, endotracheal intubation and extubation in abdominal surgeries.

Methods: A hundred and twenty patients (aging from 18 to 65, ASA class I or II, Mallampati grade I) were randomly divided into 4 groups. Fentanyl 1g kg-1 (n = 30), Esmolol 1 mg kg-1 (n = 30), Lidocaine 1 mg kg-1 (n = 30) and NaCl 0.9% 10 mL (Control group, n = 30) were administered before induction and extubation. Heart rate, systolic arterial pressure and diastolic arterial pressure were recorded before anesthesia induction and at laryngoscopy, at 1st, 3rd ,5th and 10th minutes of intubation, and then at the end of surgery before extubation, and at 1st, 3rd, 5th, and 10th minutes following extubation. Amounts of the administered drugs and side effects were recorded.

Results: The heart rates and the arterial blood pressures values of the study groups after intubation and extubation were lower than those in the control group (P < 0.01). The heart rates, the systolic and diastolic arterial blood pressure values after intubation and extubation at 1st, 3th, and 5th minutes were significantly lower in esmolol group when compared to fentanyl and lidocaine groups (P < 0.05). In all other measurement times, there was no any different of hemodynamic among the three groups.

Conclusion: When administered before induction and emergency of anesthesia 1 mg kg1of esmolol and lidocaine, and 1g kg-1 of fentanyl are effective in suppressing the hemodynamic response to laryngoscopy, intubation and extubation. Esmolol may be more effective to prevent those responses comparing fentanyl and lidocaine. Furthermore studies regarding the dose of those drugs should be required.



Hemodynamic response; Intubation; Extubation; Esmolol; Lidocaine; Fentanyl

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics






Journal of Current Surgery, quarterly, ISSN 1927-1298 (print), 1927-1301 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.