An Adenoneuroendocrine Collision Tumor of the Pancreas: A Case Report

Christine Chung, Muhammad Bassel Darwish, Patrick James McLaren, Annie Laurie Benzie, Wareef Kabbani, Edward Cho, Houssam Osman, Dhiresh Rohan Jeyarajah


Collision tumors, specifically adenoneuroendocrine tumors of the pancreas, are rare. Here we present a 57-year-old female patient with neurofibromatosis who presented with 2 months of nausea, vomiting, and epigastric pain. Imaging and endoscopy revealed severe narrowing of the third portion of the duodenum and an incidental adrenal mass. She underwent an exploratory laparotomy, right adrenalectomy, and pancreaticoduodenectomy. Pathology revealed a 4.7 cm pT3bN2M0R1 peri-ampullary combined poorly differentiated carcinoma and grade 1 neuroendocrine tumor. Due to the small number of reported cases of mixed adenoneuroendocrine carcinoma of the pancreas, clinical behavior remains unclear and definitive management approaches have not been established.

J Curr Surg. 2021;11(4):87-96


Collision tumor; Pancreas; Pancreaticoduodenectomy; Pancreatic ductal adenocarcinoma; Neuroendocrine tumor

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